Centrosomes, chromosome instability (CIN) and aneuploidy
نویسندگان
چکیده
منابع مشابه
Centrosomes, chromosome instability (CIN) and aneuploidy.
Each time a cell divides its chromosome content must be equally segregated into the two daughter cells. This critical process is mediated by a complex microtubule based apparatus, the mitotic spindle. In most animal cells the centrosomes contribute to the formation and the proper function of the mitotic spindle by anchoring and nucleating microtubules and by establishing its functional bipolar ...
متن کاملOriginal CIN: reviewing roles for APC in chromosome instability
You may have seen the bumper sticker "Eve was framed." Thousands of years of being blamed for original sin and still many wonder, where's the evidence? Today, the tumor suppressor adenomatous polyposis coli (APC) may have the same complaint about accusations of a different type of CIN, chromosome instability. A series of recent papers, including three in this journal, propose that loss of APC f...
متن کاملMeiotic-Like Division to a Aneuploidy: Chromosomal Instability (CIN), Cell-Senescence and Cancer
An understanding of cancer cell heterogeneity requires knowledge of mechanisms for somatic cell variation. For plant (galls) and animals alike, such genetic cell differences can arise from mutations, somatic crossing over, segregation mistakes and from certain viral infection. This latter route for some DNAviruses is an early virus-induced change to polyploid cells which is also increasingly be...
متن کاملChromosomal Instability, Aneuploidy, and Cancer
The link between aneuploidy and cancer has been recognized over a century ago (1). Abnormalities in chromosome copy numbers arise from persistent errors in chromosome segregation during cell division, a process known as chromosomal instability (CIN) (2). CIN is a principal contributor to genetic heterogeneity in cancer (3) and is an important determinant of clinical prognosis and therapeutic re...
متن کاملMitotic Slippage Process Concealed Cancer-Sought Chromosome Instability Mechanism (S-CIN)
Official (NIH) cancer investigation is on identification of inherited cancer genes in you and me for early interventions, and for use of such knowledge in therapy. In this review the emphasis is on the unknown cancer initiation, and on the question of a mechanism for inherited CIN (chromosomal instability). Evidence for fitness increased cells from the mitotic slippage process (in vivo/in vitro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2012
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2012.10.006